Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2기계 학습과 결합된 펩티드 마이크로어레이는 SARS-CoV-2에 대한 중화 기능을 가진 인간 항체 반응의 개별 에피토프를 나타냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] anti-SARS-CoV-2 antibody Antibody binding assays binding epitope capture causative agent cellular coronavirus coronavirus SARS-CoV-2 Course COVID-19 detectable epitope Epitopes human antibody response IgA IgG IgM antibody immunoassays incubated infected with SARS-CoV-2 machine learning Microarray N-terminus negative control samples neutralization neutralization assays Neutralizing Neutralizing antibodies nine overlapping Patient peptide peptide arrays peptides positive protective effect Protective effects random Random forest response S protein SARS CoV SARS CoV-2 SARS-CoV-2 sera serology Serology. Specific structural protein structural proteins the disease the S protein vaccine candidate vaccine candidates Viral [DOI] 10.1080/22221751.2022.2057874 PMC 바로가기 [Article Type] Article
Evaluation of the efficacy of four anti-SARS-CoV-2 antibodies after vaccination using kits from two manufacturers: A prospective, longitudinal, cohort study at 11 serial time points within 160 daysArticle Published on 2022-11-012022-11-15 Journal: International immunopharmacology [Category] SARS, 진단, 치료기술, [키워드] Accuracy acute respiratory syndrome Affect anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibodies antibody Antibody detection cohort study Consistency CoronaVac coronavirus COVID-19 Efficacy evaluated half-live IgG antibody IgM antibody immune response less moderate Neutralizing antibodies neutralizing antibody SARS-CoV-2 SARS-CoV-2 vaccines subject the vaccine total antibodies total antibody vaccination vaccination. Vaccine [DOI] 10.1016/j.intimp.2022.109285 PMC 바로가기
Evaluation of five immunoassays and one lateral flow immunochromatography for anti-SARS-CoV-2 antibodies detectionArticle Published on 2022-11-012022-11-15 Journal: Enfermedades infecciosas y microbiologia clinica ( [Category] SARS, 진단, 치료기술, [키워드] addition anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody approach caused CLIA CLIA assays Clinical practice complementary coronavirus SARS-CoV-2 COVID-19 COVID-19 patient criteria diagnostic ELISA English evaluated FIVE greater healthcare worker healthy IgG IgM IgM antibody immunoassay immunochromatographic test immunochromatography Inmunocromatografía involved lateral flow Pandemia pandemic para performed Rapid test ROC ROC curves RT-PCR SARS-CoV-2 SARS-CoV-2 coronavirus sensitivity Serología. serological serology serum sample Sin Spanish specificity Support Vaccine [DOI] 10.1016/j.eimce.2020.12.007 PMC 바로가기
Features of the Humoral Response to Infection, Vaccination, and Revaccination during COVID-19Article Published on 2022-10-012022-11-15 Journal: Bulletin of experimental biology and medicine [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] antibody antibody levels Antigen Blood coronavirus COVID-19 Gam-COVID-Vac Gam-COVID-Vac vaccine Humoral immunity humoral immunity. IgG antibody IgM IgM antibodies IgM antibody majority medium observation period Patient recovered patients Registered response revaccination S-protein SARS-CoV-2 sera serum subject the disease the SARS-CoV-2 virus Urine vaccination virus-neutralizing [DOI] 10.1007/s10517-022-05620-1 PMC 바로가기
Evaluation of eleven immunochromatographic assays for SARS-CoV-2 detection: investigating the dengue cross-reactionArticle Published on 2022-09-302022-11-15 Journal: Revista do Instituto de Medicina Tropical de São [Category] SARS, 진단, 치료기술, [키워드] blood donor collected confirmed case COVID-19 cross-reactivity demonstrated Diagnosis diagnostic disease Diseases evaluate evaluated feasible IgG and IgM IgM antibody immunochromatographic assay lack onset of symptom pandemic Patient RT-PCR SARS-CoV-2 sensitivity Sensitivity and specificity serum sample specificity Spread [DOI] 10.1590/S1678-9946202264063 PMC 바로가기
IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SARS-CoV-2기억 B 세포에서 파생된 IgM 항체는 SARS-CoV-2의 강력한 교차 변형 중화제입니다Article Published on 2022-09-052022-09-11 Journal: The Journal of Experimental Medicine [Category] MERS, SARS, 변종, 진단, [키워드] affinities affinity Antigen B cell receptor convalescent convalescent sera domain Donor donors Efficacy Epitopes highlight Humoral immunity IgG IgG antibodies IgG antibody IgM IgM antibody immune memory Immunity mAb mAbs memory memory B cell memory B cells monoclonal antibody monomeric neutralizing antibody neutralizing capacity pathogen polyclonal sera responsible retained SARS-CoV-2 SARS-CoV-2 viral therapeutic potential variant Viral while [DOI] 10.1084/jem.20220849 PMC 바로가기 [Article Type] Article
Immunogenicity and safety of an inactivated SARS-CoV-2 vaccine in people living with HIV: A cross-sectional studyHIV 보균자에서 비활성화된 SARS-CoV-2 백신의 면역원성과 안전성: 단면 연구Article Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Analysis antibody Antiretroviral therapy appear ART CD4+ T cell CD4+ T cells CD4+ T-cell chemiluminescence Chinese control group COVID-19 COVID-19 vaccine cross-sectional delta variant Delta variants detect Efficacy and safety enzyme enzyme immunoassay healthy individual Human immunodeficiency virus IgG IgM antibodies IgM antibody immunoassay immunodeficiency immunogenicity inactivated indicated individual Mild multivariable analysis NAb Neutralizing neutralizing antibody Odds ratio PLWH proportion Safe SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2-specific IgG self-limiting seropositive Seropositivity serum IgG serum levels Side effect Side effects side effects. significantly higher T cells titers vaccination was used wild-type SARS-CoV-2 with HIV [DOI] 10.1002/jmv.27872 PMC 바로가기 [Article Type] Article
One-Year Sustained Cellular and Humoral Immunities in Coronavirus Disease 2019 (COVID-19) Convalescents코로나바이러스 질병 2019(COVID-19) 회복기의 1년 지속 세포 및 체액 면역Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, 치료기술, 치료법, [키워드] antibodies antibody Antigen Asymptomatic cellular chemiluminescence immunoassay circulating cohort study conducted convalescent COVID-19 cytokine detectable disease disease onset disease severity ELISA ELISPOT enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay enzyme-linked immunospot assay feature flow cytometry Humoral immunity IgG antibodies IgM IgM antibody immune immune memory Immunity Immunoglobulin individual intracellular cytokine staining membrane memory Microparticle Mild moderate N proteins neutralization neutralizing antibody neutralizing antibody. nucleocapsid protein Nucleocapsid proteins positive SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2-specific antibodies SARS-CoV-2-specific IgG SARS-CoV-2-specific T-cell response severe disease specific antibodies specific IgG antibodies T cells T-cell T-cell responses the SARS-CoV-2 was tested were assessed [DOI] 10.1093/cid/ciab884 PMC 바로가기 [Article Type] Article
Effectiveness and adherence to closed face shields in the prevention of COVID-19 transmission: a non-inferiority randomized controlled trial in a middle-income setting (COVPROSHIELD)COVID-19 전염 예방에 대한 폐쇄형 안면 보호구의 효과 및 준수: 중간 소득 환경에서의 비열등 무작위 대조 시험(COVPROSHIELD)Randomized Controlled Trial Published on 2022-08-202022-09-11 Journal: Trials [Category] SARS, 임상, 치료기술, [키워드] 95% CI active control group Antibody test assigned benefit Chain Reaction clinical clinical trial Closed face shield combined use Community condition COVID-19 COVID-19 pandemic cross crowding determine disease Effectiveness face Face mask Face masks Face shield Follow-up follow-up period groups highly active IgM antibody inferiority intention-to-treat analysis intervention group limit Mask Masks mitigate non-inferiority Open-label participant per-protocol analysis polymerase chain polymerase chain reaction positive Prevent prevention of COVID-19 Primary outcome Randomized Randomized controlled trial Randomly reverse transcription risk risk difference SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2 test SARS-CoV-2 transmission SARS-CoV-2. setting Spread surgical test result two groups Ventilation Viral transmission [DOI] 10.1186/s13063-022-06606-0 PMC 바로가기 [Article Type] Randomized Controlled Trial
Active surveillance and early detection of community transmission of SARS-CoV-2 Mu variant (B.1.621) in the Brazilian Amazon브라질 아마존에서 SARS-CoV-2 Mu 변종(B.1.621) 지역사회 전파에 대한 능동적 감시 및 조기 탐지Article Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Active surveillance All participants Amino acid amino acid substitution Antigen assist Asymptomatic B.1.621 blood sample Blood samples Brazilian Amazon Chain Reaction circulating city collected Community community transmission Contact tracing country COVID-19 patient Diagnosis diagnostic test ELISA testing Emergency epidemiological data followed by genomic genomic sequencing Genomic surveillance highlight household contacts identify IgA IgG IgG levels IgM antibody IgM antibody levels individual infected individual information mild symptoms Mu variant nasopharyngeal swabs one patient ORF1a ORF7a outpatients Participants polymerase chain reaction Porto prospective cohort Rapid diagnostic test reference sequence Reverse transcription-polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2. sequenced specimen Surveillance Swab tested Travel variant virus virus viruses [DOI] 10.1002/jmv.27686 PMC 바로가기 [Article Type] Article